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Báo cáo y học: "Temporal variation in the recovery from impairment in adriamycin-induced wound healing in rats"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Temporal variation in the recovery from impairment in adriamycin-induced wound healing in rats. | Journal of Circadian Rhythms BioMed Central Research Temporal variation in the recovery from impairment in adriamycin-induced wound healing in rats Haluk Alagol1 Soykan Dinc1 Bilgen Basgut2 and Nurettin Abacioglu 2 Open Access Address Department of General Surgery Ankara Oncology Training and Research Hospital Demetevler Ankara Turkey and 2Department of Pharmacology Gazi University 06330 Hipodrom Ankara Turkey Email Haluk Alagol - halagol@gmail.com Soykan Dinc - soykanege@gmail.com Bilgen Basgut - bilgenh@gazi.edu.tr Nurettin Abacioglu - nabaci@gazi.edu.tr Corresponding author Published 10 October 2007 Received 30 May 2007 Accepted 10 October 2007 Journal of Circadian Rhythms 2007 5 6 doi l0.ll86 l740-339l-5-6 This article is available from http www.jcircadianrhythms.com content 5 l 6 2007 Alagol et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background An adriamycin-induced impairment of wound healing has been demonstrated experimentally in rats. The purpose of this study is to investigate a possible temporal variation in recovery from the impairment of wound healing caused by adriamycin administration. Methods The subjects were 120 female Spraque-Dawley rats. They were divided into eight groups undergoing adriamycin administration 8 mg kg i.v. at 9 a.m. or 9 p.m. on day 0 and laparotomy on day 0 7 l4 or 2l. Blast pressures were recorded after the incision line had been opened and tissue samples were kept at -30 C for later measurement of hydroxyproline levels. Results Adriamycin treatment in rats at 9 p.m. resulted in significantly lower blast pressure levels than treatment at 9 a.m. between days 7 and 2l indicating a lag effect