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Báo cáo y học: "CLOCK is suggested to associate with comorbid alcohol use and depressive disorders"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: CLOCK is suggested to associate with comorbid alcohol use and depressive disorders. | Sjoholm et al. Journal of Circadian Rhythms 2010 8 1 http www.jcircadianrhythms.eom content 8 1 1 JOURNAL OF CIRCADIAN RHYTHMS RESEARCH Open Access CLOCK is suggested to associate with comorbid alcohol use and depressive disorders Louise K Sjoholm1 Leena Kovanen2 3 Sirkku T Saarikoski3 Martin Schalling1 Catharina Lavebratt1 Timo Partonen2 Abstract Background Depression and alcohol abuse or dependence AUD co-occur in the general population more frequently than expected by chance. Alcohol use influences the circadian rhythms generated by the central pacemaker in the suprachiasmatic nucleus and circadian rhythm alterations in turn are common in depressive disorders as well as among persons addicted to alcohol. Methods 32 SNPs in 19 circadian clockwork related genes were analyzed using DNA from 76 individuals with comorbid depression and AUD 446 individuals with AUD and 517 healthy controls with no psychiatric diagnosis. The individuals participated in a nationwide health examination study representative of the general population aged 30 and over in Finland. Results The CLOCK haplotype TTGC formed by SNPs rs3805151 rs2412648 rs11240 and rs2412646 was associated with increased risk for comorbidity OR 1.65 95 CI 1.14-2.28 P 0.0077 . The SNPs of importance for this suggestive association were rs2412646 and rs11240 indicating location of the functional variation in the block downstream rs2412648. There was no indication for association between CLOCK and AUD. Conclusion Our findings suggest an association between the CLOCK gene and the comorbid condition of alcohol use and depressive disorders. Together with previous reports it indicates that the CLOCK variations we found here may be a vulnerability factor to depression given the exposure to alcohol in individuals having AUD. Background Depression alcohol abuse or dependence AUD as well as other affective disorders and substance use disorders SUD co-occur in the general population more frequently than expected by chance 1 2