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Báo cáo y học: "Gene polymorphisms in APOE, NOS3, and LIPC genes may be risk factors for cardiac adverse events after primary CABG"

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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Gene polymorphisms in APOE, NOS3, and LIPC genes may be risk factors for cardiac adverse events after primary CABG. | Journal of Cardiothoracic Surgery BioMed Central Research article Gene polymorphisms in APOE NOS3 and LIPC genes may be risk factors for cardiac adverse events after primary CABG Sandra Eifert 1 Astrid Rasch1 Andres Beiras-Fernandez1 Georg Nollert1 Bruno Reichart1 and Peter Lohse2 Address Department of Cardiac Surgery Ludwig Maximilians University Munich Germany and - Department of Clinical Chemistry Ludwig Maximilians University Munich Germany Email Sandra Eifert - seifert@med.uni-muenchen.de Astrid Rasch - Astrid.Rasch@med.uni-muenchen.de Andres Beiras- Fernandez - abeiras@med.uni-muenchen.de Georg Nollert - georg.nollert@siemens.com Bruno Reichart - breichart@med.uni-muenchen.de Peter Lohse - plohse@med.uni-muenchen.de Corresponding author Open Access Published 19 August 2009 Received 24 March 2009 Journal of Cardiothoracic Surgery 2009 4 46 doi l0.ll86 l749-8090-4-46 Accepted 19 August 2009 This article is available from http www.cardiothoracicsurgery.Org content 4 1 46 2009 Eifert et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Introduction Coronary artery disease progression after primary coronary artery bypass grafting may beside classical atherosclerosis risk factors be depending on genetic predisposition. Methods We investigated 192 CABG patients 18 female age 60.9 7.4 years . Clinically cardiac adverse events were defined as need for reoperation n 88 46 reintervention n 58 30 or angina n 89 46 . Mean follow-up time measured 10.1 5.1 years. Gene polymorphisms ApoE NOS3 LIPC CETP SERPINE-1 Prothrombin were investigated separately and combined gene risk profile . Results Among classical risk factors arterial .

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