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Báo cáo khoa hoc:" Immunological parameters in girls with Turner syndrome"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Immunological parameters in girls with Turner syndrome | Journal of Negative Results in BioMedicine BioMed Central Research Open Access Immunological parameters in girls with Turner syndrome Annika E Stenberg Lisskulla Sylvént2 Carl GM Magnussont3 and Malou Hultcrantzt1 Address 1Dept. of Otorhinolaryngology Karolinska University Hospital Stockholm Sweden 2Dept. of Woman and Child Health Karolinska University Hospital Stockholm Sweden and 3Dept. Clin. Chemistry Engelholm hospital Engelholm Sweden Email Annika E Stenberg - Annika.Stenberg@cns.ki.se Lisskulla Sylvén - lisskulla.sylven@karolinska.se Carl GM Magnusson - Carl.Magnusson@nvs.skane.se Malou Hultcrantz - malou.hultcrantz@karolinska.se Corresponding author fEqual contributors Published 25 November 2004 Received 23 October 2002 Accepted 25 November 2004 Journal of Negative Results in BioMedicine 2004 3 6 doi 10.1186 1477-5751-3-6 r This article is available from http www.jnrbm.com content 3 1 6 2004 Stenberg et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Disturbances in the immune system has been described in Turner syndrome with an association to low levels of IgG and IgM and decreased levels of T- and B-lymphocytes. Also different autoimmune diseases have been connected to Turner syndrome 45 X thyroiditis being the most common. Besides the typical features of Turner syndrome short stature failure to enter puberty spontaneously and infertility due to ovarian insufficiency ear problems are common recurrent otitis media and progressive sensorineural hearing disorder . Levels of IgG IgA IgM IgD and the four IgG subclasses as well as T- and B-lymphocyte subpopulations were investigated in 15 girls with Turners syndrome to examine whether an immunodeficiency may be the cause of their high incidence of otitis .