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Báo cáo y học: " Enhanced release of IgE-dependent early phase mediators from nasal polyp tissue"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Enhanced release of IgE-dependent early phase mediators from nasal polyp tissue. | Journal of Inflammation BioMed Central Research Enhanced release of IgE-dependent early phase mediators from nasal polyp tissue Joke Patou 1 Gabriele Holtappels1 Karen Affleck2 Philippe Gevaert1 Claudina Perez-Novo1 Paul Van Cauwenberge1 and Claus Bachert1 Open Access Address 1Upper Airways Research Laboratory Department of Otorhinolaryngology Ghent University Ghent Belgium and 2GSK Stevenage SG1 2NY UK Email Joke Patou - Joke.Patou@ugent.be Gabriele Holtappels - Gabriele.Holtappels@ugent.be Karen Affleck - Karen.x.affleck@gsk.com Philippe Gevaert - Philippe.gevaert@ugent.be Claudina Perez-Novo - claudina.pereznovo@ugent.be Paul Van Cauwenberge - paul.vancauwenberge@ugent.be Claus Bachert-claus.bachert@ugent.be Corresponding author Published 20 April 2009 Received 14 September 2008 Journal of Inflammation 2009 6 11 doi 10.1186 1476-9255-6-11 Accepted 20 April 2009 This article is available from http www.journal-inflammation.cOm content 6 1 1 1 2009 Patou et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The mast cell is a crucial effector cell in allergic rhinitis and other inflammatory diseases. During the acute allergic reaction preformed mediators such as histamine but also de novo produced mediators such as leukotrienes LTC4 D4 E4 and prostaglandins PGD2 are released. Mast cells represent targets for therapeutic intervention and thus a human ex-vivo model to stimulate mast cells taken from mucosal sites would be instrumental for drug intervention studies. We have aimed to activate mast cells within ex-vivo human nasal tissue by IgE anti-IgE specific e chain specific stimulations and in this respect to test the usability of nasal polyps versus inferior turbinates Methods Biopsy samples were .