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Báo cáo y học: "Cleavage of functional IL-2 receptor alpha chain (CD25) from murine corneal and conjunctival epithelia by MMP-9"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Cleavage of functional IL-2 receptor alpha chain (CD25) from murine corneal and conjunctival epithelia by MMP-9. | Journal of Inflammation BioMed Central Research Cleavage of functional IL-2 receptor alpha chain CD25 from murine corneal and conjunctival epithelia by MMP-9 Cintia S De Paiva1 Kyung-Chul Yoon1 2 Solherny B Pangelinan1 Sapa Pham1 Larry M Puthenparambil1 Eliseu Y Chuang1 William J Farley1 Michael E Stern3 De-Quan Li1 and Stephen C Pflugfelder 1 Open Access Address 1Ocular Surface Center Department of Ophthalmology Cullen Eye Institute Baylor College of Medicine Houston Texas USA 2Department of Ophthalmology Chonnam National University Medical School and Hospital Gwangju South Korea and 3Allergan Irvine CA USA Email Cintia S De Paiva - cintiadp@bcm.tm.edu Kyung-Chul Yoon - kcyoon@jnu.ac.kr Solherny B Pangelinan - solbelouche@comcast.net Sapa Pham - sapapham@gmail.com Larry M Puthenparambil - lp147846@bcm.edu Eliseu Y Chuang - eliseu88@yahoo.com William J Farley - wfarley@bcm.tmc.edu Michael E Stern - stern_Michael@allergan.com De-Quan Li - dequanl@bcm.tmc.edu Stephen C Pflugfelder - stevenp@bcm.tmc.edu Corresponding author Published 31 October 2009 Journal of Inflammation 2009 6 31 doi l0.ll86 l476-9255-6-3l Received 9 June 2009 Accepted 31 October 2009 This article is available from http www.iournal-inflammation.cOm content 6 l 3l 2009 De Paiva et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background IL-2 has classically been considered a cytokine that regulates T cell proliferation and differentiation signaling through its heterotrimeric receptor IL-2R consisting of a CD25 p CDl22 Y chains CDl32 . Expression of IL-2R has also been detected in mucosal epithelial cells. Soluble IL-2Ra CD25 has been reported as an inflammatory marker. We evaluated the expression of CD25 and CDl22 in the ocular surface .