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Báo cáo y học: " Ingestion of 10 grams of whey protein prior to a single bout of resistance exercise does not augment "

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: ngestion of 10 grams of whey protein prior to a single bout of resistance exercise does not augment | Cooke et al. Journal of the International Society of Sports Nutrition 2011 8 18 http www.jissn.eom content 8 1 18 jissn journal of the international lociety of rporti nutrition RESEARCH ARTICLE Open Access Ingestion of 10 grams of whey protein prior to a single bout of resistance exercise does not augment Akt mTOR pathway signaling compared to carbohydrate 1.3 1 14 11 1.5 Matthew B Cooke Paul La Bounty Thomas Buford Brian Shelmadine Liz Redd Geoffrey Hudson and Darryn S Willoughby1 2 Abstract Background This study examined the effects of a whey protein supplement in conjunction with an acute bout of lower body resistance exercise in recreationally-active males on serum insulin and insulin like growth factor 1 IGF-1 and Akt mTOR signaling markers indicative of muscle protein synthesis insulin receptor substrate 1 IRS-1 AKT mammalian target of rapamycin mTOR p70S6 kinase p70S6K and 4E-binding protein 1 4E-BP1 . Methods In a randomized double-blind cross-over design 10 males ingested 1 week apart either 10 g of whey protein 5.25 g EAAs or carbohydrate maltodextrose 30 min prior to a lower-body resistance exercise bout. The resistance exercise bout consisted of 4 sets of 8-10 reps at 80 of the one repetition maximum RM on the angled leg press and knee extension exercises. Blood and muscle samples were obtained prior to and 30 min following supplement ingestion and 15 min and 120 min post-exercise. Serum and muscle data were analyzed using two-way ANOVA. Results No significant differences were observed for IGF-1 p 0.05 . A significant main effect for Test was observed for serum insulin p 0.01 at 30 min post-ingestion and 15 and 120 min post-exercise with no Supplement X Test interaction p 0.05 . For the Akt MTOR signaling intermediates no significant Supplement X Test interactions were observed p 0.05 . However significant main effects for Test were observed for phosphorylated concentrations of IRS mTOR and p70S6K as all were elevated at 15 min post-exercise p 0.05 . .