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báo cáo khoa học:" Development of the ATAQ-IPF: a tool to assess quality of life in IPF"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Development of the ATAQ-IPF: a tool to assess quality of life in IPF | Swigris et al. Health and Quality of Life Outcomes 2010 8 77 http www.hqlo.eom content 8 1 77 HEALTH AND QUALITY of life outcomes RESEARCH Open Access Development of the ATAQ-IPF a tool to assess quality of life in IPF 1 23 1 1 4 Jeffrey J Swigris Sandra R Wilson Kathy E Green David B Sprunger Kevin K Brown Frederick S Wamboldt Abstract Background There is no disease-specific instrument to assess health-related quality of life HRQL in patients with idiopathic pulmonary fibrosis IPF . Methods Patients perspectives were collected to develop domains and items for an IPF-specific HRQL instrument. We used item variance and Rasch analysis to construct the ATAQ-IPF A Tool to Assess Quality of life in IPF . Results The ATAQ-IPF version 1 is composed of 74 items comprising 13 domains. All items fit the Rasch model. Domains and the total instrument possess acceptable psychometric characteristics for a multidimensional questionnaire. The pattern of correlations between ATAQ-IPF scores and physiologic variables known to be important in IPF along with significant differences in ATAQ-IPF scores between subjects using versus those not using supplemental oxygen support its validity. Conclusions Patient-centered and careful statistical methodologies were used to construct the ATAQ-IPF version 1 an IPF-specific HRQL instrument. Simple summation scoring is used to derive individual domain scores as well as a total score. Results support the validity of the ATAQ-IPF and future studies will build on that validity. Introduction Patient reported outcomes PRO such as quality of life QOL or health-related QOL HRQL are commonly used endpoints in clinical studies and therapeutic trials in patients with pulmonary diseases. Instruments that assess PRO focus on the perceptions of patients with the condition of interest as such they generate meaningful data on disease effects not captured by other outcome measures. HRQL instruments are generic or disease-specific. The merit of disease-specific .