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Báo cáo y học: " Seroprevalence of hepatitis C in type 2 diabetes: evidence for a positive association"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Seroprevalence of hepatitis C in type 2 diabetes: evidence for a positive association | Jadoon et al. Virology Journal 2010 7 304 http www.virologyj.eom content 7 1 304 VIROLOGY JOURNAL RESEARCH Open Access Seroprevalence of hepatitis C in type 2 diabetes evidence for a positive association Nauman A Jadoon Mohammad A Shahzad Rehan Yaqoob Mansoor Hussain Naseema Ali Abstract Background There is a growing body of literature on the relationship of Hepatitis C virus infection HCV and type 2 diabetes mellitus T2DM . However there are certain gaps in literature and the data is inconclusive. This study was therefore carried out to determine the prevalence of HCV infection in diabetic patients and to elucidate the presence of any possible relationship between HCV and T2DM in this region. Methods Serologic testing for anti-HCV antibody was done on a sample of 3000 individuals with T2DM visiting Diabetes Clinic of Nishtar Medical College Hospital Multan and 10 000 volunteer blood donors visiting blood bank of the same hospital during the study period using Accurate rapid immunochromatographic kits which was later confirmed by using Chemelex S.A third generation ELISA kit for positive cases. Data about various variables was collected from diabetic patients using a structured questionnaire after taking informed consent. Results Prevalence rate of 13.7 for HCV infection was recorded among subjects having T2DM with seropositivity rate of 4.9 among the control group of volunteer blood donors without diabetes. The patients with T2DM were more likely to have HCV infection as compared to the control group OR 3.03 95 CI 2.64-3.48 p 0.001 . Diabetic patients with age above 55 years had higher prevalence rate as compared to younger individuals. Male patients had significantly high seropositivity as compared to female patients 15.3 vs. 12.4 p 0.02 . Those with duration of diabetes 11 years and above and the ones with good glycemic control had higher seroprevalence rates of 18.2 and 18.7 respectively. There was no statistically significant difference among subjects when the