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Báo cáo khoa học: "Characterisation of a GII-4 norovirus variant-specific surface-exposed site involved in antibody binding"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Characterisation of a GII-4 norovirus variant-specific surface-exposed site involved in antibody binding | Virology Journal BioMed Central Open Access Characterisation of a GII-4 norovirus variant-specific surface-exposed site involved in antibody binding David J Allen 1 2 Rob Noad2 4 Dhan Samuel3 Jim J Gray1 Polly Roy2 and Miren Iturriza-Gomara1 Address 1Enteric Virus Unit Virus Reference Department Centre for Infections Health Protection Agency Colindale London NW9 5EQ 2Pathogen Molecular Biology Unit Department of Infectious Tropical Diseases London School of Hygiene Tropical Medicine Keppel Street London WC1 5HT 3Serology Development Unit Virus Reference Department Centre for Infections Health Protection Agency Colindale London NW9 5EQ and 4Department of Pathology and Infectious Diseases Royal Veterinary College Hawkshead Lane Hatfield AL9 7TA UK Email David J Allen - davidjamesallen@gmail.com Rob Noad - rnoad@rvc.ac.uk Dhan Samuel - dhan.samuel@hpa.org.uk Jim J Gray - jim.gray@hpa.org.uk Polly Roy - polly.roy@lshtm.ac.uk Miren Iturriza-Gomara - miren.iturriza@hpa.org.uk Corresponding author Published 25 September 2009 Received 25 August 2009 Accepted 25 September 2009 Virologyjournal 2009 6 150 doi 10.1186 1743-422X-6-150 This article is available from http www.virologyj.cOm content 6 1 150 2009 Allen et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The human noroviruses are a highly diverse group of viruses with a single-stranded RNA genome encoding a single major structural protein VP1 which has a hypervariable domain P2 domain as the most exposed part of the virion. The noroviruses are classified on the basis of nucleotide sequence diversity in the VPI-encoding ORF2 gene which divides the majority of human noroviruses into two genogroups GI and GII . GII-4 noroviruses are the major aetiological .