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Báo cáo khoa học: " Identification of novel host-oriented targets for Human Immunodeficiency Virus type 1 using Random "

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Identification of novel host-oriented targets for Human Immunodeficiency Virus type 1 using Random | Virology Journal BioMed Central Open Access Identification of novel host-oriented targets for Human Immunodeficiency Virus type 1 using Random Homozygous Gene Perturbation Hanwen Mao Hanson Chen Zena Fesseha Shaojing Chang Huong Ung-Medoff Jessica Van Dyke Manu Kohli Wu-Bo Li Michael Goldblatt and Michael S Kinch Address Functional Genetics Inc. 708 Quince Orchard Road Gaithersburg MD 20878 USA Email Hanwen Mao - hmao@functional-genetics.com Hanson Chen - hchen@functional-genetics.com Zena Fesseha - zfesseha@functional-genetics.com Shaojing Chang - schang@functional-genetics.com Huong Ung-Medoff-hung@functional-genetics.com Jessica Van Dyke - jvandyke@functional-genetics.com Manu Kohli - mkohli@functional-genetics.com Wu-Bo Li - wli@functional-genetics.com Michael Goldblatt - mgoldblatt@functional-genetics.com Michael S Kinch - mkinch@functional-genetics.com Corresponding author Published 29 September 2009 Received 10 July 2009 Accepted 29 September 2009 Virologyjournal 2009 6 154 doi 10.1186 1743-422X-6-154 This article is available from http www.virologyj.cOm content 6 1 154 2009 Mao et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Human Immunodeficiency Virus HIV is a global threat to public health. Current therapies that directly target the virus often are rendered ineffective due to the emergence of drugresistant viral variants. An emerging concept to combat drug resistance is the idea of targeting host mechanisms that are essential for the propagation of the virus but have a minimal cellular effect. Results Herein using Random Homozygous Gene Perturbation RHGP we have identified cellular targets that allow human MT4 cells to survive otherwise lethal infection by a wild type HIV-1NL4-3. These .