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Báo cáo khoa học: "Identification of a novel picornavirus related to cosaviruses in a child with acute diarrhea"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Identification of a novel picornavirus related to cosaviruses in a child with acute diarrhea | Virology Journal BioMed Central Open Access Short report Identification of a novel picornavirus related to cosaviruses in a child with acute diarrhea Lori R Holtz1 Stacy R Finkbeiner2 Carl D Kirkwood3 and David Wang 2 Address Department of Pediatrics Washington University School of Medicine St. Louis MO USA - Departments of Molecular Microbiology and Pathology and Immunology Washington University School of Medicine St. Louis MO USA and 3Enteric Virus Research Group Murdoch Childrens Research Institute Royal Children s Hospital Victoria Australia Email Lori R Holtz - holtz_l@kids.wustl.edu Stacy R Finkbeiner - srfinkbe@artsci.wustl.edu Carl D Kirkwood - carl.kirkwood@mcri.edu.au David Wang - davewang@wustl.edu Corresponding author Published 22 December 2008 Received 6 December 2008 __IAAAO r.iro J-I.IA I ioz i-7a- amv f ICO Accepted 22 December 2008 Virology Journal 2008 5 159 doi 10.1186 1743-422X-5-159 This article is available from http www.virologyj.cOm content 5 1 159 2008 Holtz et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Diarrhea the third leading infectious cause of death worldwide causes approximately 2 million deaths a year. Approximately 40 of these cases are of unknown etiology. We previously developed a metagenomic strategy for identification of novel viruses from diarrhea samples. By applying mass sequencing to a stool sample collected in Melbourne Australia from a child with acute diarrhea one 395 bp sequence read was identified that possessed only limited identity to known picornaviruses. This initial fragment shared only 55 amino acid identity to its top BLAST hit the VP3 protein of Theiler s-like virus .