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Báo cáo khoa học: "Oral vaccination with a recombinant Salmonella vaccine vector provokes systemic HIV-1 subtype C Gag-specific CD4+ Th1 and Th2 cell immune responses in mice"

Oral vaccination with a recombinant Salmonella vaccine vector provokes systemic HIV-1 subtype C Gag-specific CD4+ Th1 and Th2 cell immune responses in mice | Virology Journal BioMed Central Research Open Access Oral vaccination with a recombinant Salmonella vaccine vector provokes systemic HIV-I subtype C Gag-specific CD4 Thl and Th2 cell immune responses in mice Nyasha Chin ombe 1 William R Bourn1 4 Anna-Lise Williamson1 2 and Enid G Shephard 1 3 Address Institute of Infectious Disease and Molecular Medicine Faculty of Health Sciences University of Cape Town Observatory 7925 Cape Town South Africa 2National Health Laboratory Services Groote Schuur Hospital Cape Town South Africa 3Department of Medicine Faculty of Health Sciences University of Cape Town Observatory 7925 Cape Town South Africa and 4Kapa Biosystems Pty Ltd Observatory 7925 Cape Town South Africa Email Nyasha Chin ombe - Nyasha.Chinombe@uct.ac.za William R Bourn - william.bourn@kapabiosystems.com Anna-Lise Williamson - Anna-Lise.Williamson@uct.ac.za Enid G Shephard - Enid.Shephard@uct.ac.za Corresponding author Published 25 June 2009 Received 30 April 2009 Accepted 25 June 2009 Virology Journal 2009 6 87 doi l0.ll86 l 743-422X-6-87 This article is available from http www.virologyj.cOm content 6 1 87 2009 Chin ombe et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Recombinant Salmonella vaccine vectors may potentially be used to induce specific CD4 T cell responses against foreign viral antigens. Such immune responses are required features of vaccines against pathogens such as human immunodeficiency virus type 1 HIV-1 . The aim of this study was to investigate the induction of systemic HIV- 1 -specific CD4 T helper Th responses in mice after oral immunization with a live attenuated Salmonella vaccine vector that expressed HIV- 1 subtype C Gag. Groups of BALB c mice were vaccinated orally .