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báo cáo khoa học: " Discovery of chemically induced mutations in rice by TILLING"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Discovery of chemically induced mutations in rice by TILLING | BMC Plant Biology BioMed Central Methodology article Open Access Discovery of chemically induced mutations in rice by TILLING Bradley J Till11 2 Jennifer Cooped1 Thomas H Tai3 Peter Colowit3 Elizabeth A Greene1 Steven Henikoff1 and Luca Comai 2 4 Address 1Fred Hutchinson Cancer Research Center Seattle WA 98107 USA 2Department of Biology University of Washington Box 355325 Seattle WA 98195 USA 3USDA-ARS Crops Pathology and Genetics Research Unit Department of Plant Sciences Davis CA 95616 USA and 4Section of Plant Biology and Genome Center UC Davis Davis CA 95616 USA Email Bradley J Till - btill@fhcrc.org Jennifer Cooper - jlcooper@fhcrc.org Thomas H Tai - ttai@ucdavis.edu Peter Colowit - pmcolowit@ucdavis.edu Elizabeth A Greene - eagreene@fhcrc.org Steven Henikoff - steveh@fhcrc.org Luca Comai - lcomai@ucdavis.edu Corresponding author fEqual contributors Published II April 2007 Received 2 November 2006 BMC Plant Biology 2007 7 19 doi 10.1186 1471-2229-7-19 Accepted 11 April 2007 This article is available from http www.biomedcentral.com I47I-2229 7 I9 2007 Till et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Rice is both a food source for a majority of the world s population and an important model system. Available functional genomics resources include targeted insertion mutagenesis and transgenic tools. While these can be powerful a non-transgenic unbiased targeted mutagenesis method that can generate a range of allele types would add considerably to the analysis of the rice genome. TILLING Targeting Induced Local Lesions in Genomes a general reverse genetic technique that combines traditional mutagenesis with high throughput methods for mutation discovery is such a method. Results To apply TILLING