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báo cáo hóa học:" Regression of orthotopic neuroblastoma in mice by targeting the endothelial and tumor cell compartments"

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Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Regression of orthotopic neuroblastoma in mice by targeting the endothelial and tumor cell compartments | Journal of Translational Medicine BioMed Central Open Access Regression of orthotopic neuroblastoma in mice by targeting the endothelial and tumor cell compartments Dieter Fuchs 1 Rolf Christofferson1 2 Mats Stridsberg3 Elin Lindhagen3 and Faranak Azarbayjani1 Address Department of Medical Cell Biology Uppsala University 75123 Uppsala Sweden 2Department of Woman and Child Health Uppsala University Hospital 75185 Uppsala Sweden and 3Department of Medical Sciences Uppsala University Hospital 75185 Uppsala Sweden Email Dieter Fuchs - dieter.fuchs@mcb.uu.se Rolf Christofferson - rolf.christofferson@kbh.uu.se Mats Stridsberg - mats.stridsberg@medsci.uu.se Elin Lindhagen - elin.lindhagen@medsci.uu.se Faranak Azarbayjani - faranak.azarbayjani@mcb.uu.se Corresponding author Published 12 March 2009 Received 29 September 2008 _ -T_-mno 1.1 j. .iniiozn.r7oro7Z7iz Accepted 12 March 2009 Journal of Translational Medicine 2009 7 16 doi l0.ll86 l479-5876-7-l6 This article is available from http www.translational-medicine.cOm content 7 l l6 2009 Fuchs et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background High-risk neuroblastoma has an overall five-year survival of less than 40 indicating a need for new treatment strategies such as angiogenesis inhibition. Recent studies have shown that chemotherapeutic drugs can inhibit angiogenesis if administered in a continuous schedule. The aim of this study was primarily to characterize tumor spread in an orthotopic metastatic model for aggressive MYCN-amplified neuroblastoma and secondarily to study the effects of daily administration of the chemotherapeutic agent CHS 828 on tumor angiogenesis tumor growth and spread. Methods MYCN-amplified human neuroblastoma cells IMR-32 2

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