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Báo cáo sinh học: " Experimental infection of H5N1 HPAI in BALB/c mice"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Experimental infection of H5N1 HPAI in BALB/c mice | Virology Journal BioMed Central Research Open Access Experimental infection of H5NI HPAI in BALB c mice Vasily A Evseenko Eugeny K Bukin Anna V Zaykovskaya Kirill A Sharshov Vladimir A Ternovoi George M Ignatyev and Alexander M Shestopalov Address State Research Center of Virology and Biotechnology Vector of Rospotrebnadzor Koltsovo Russia Email Vasily A Evseenko - vasily.evseenko@gmail.com Eugeny K Bukin - dr_eb@mail.ru Anna V Zaykovskaya - zaykovskaya@mail.ru Kirill A Sharshov - sharshov@yandex.ru Vladimir A Ternovoi - kern@vector.nsc.ru George M Ignatyev - marburgman@mail.ru Alexander M Shestopalov - shestopalov2@mail.ru Corresponding author Published 27 July 2007 Received 3 July 2007 Accepted 27 July 2007 Virology Journal 2007 4 77 doi l0.ll86 l 743-422X-4-77 This article is available from http www.virologyj.cOm content 4 1 77 2007 Evseenko et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background In 2005 huge epizooty of H5N1 HPAI occurred in Russia. It had been clear that territory of Russia becoming endemic for H5N1 HPAI. In 2006 several outbreaks have occurred. To develop new vaccines and antiviral therapies animal models had to be investigated. We choose highly pathogenic strain for these studies. Results A duck Tuva 0l 06 belongs to Quinghai-like group viruses. Molecular markers - cleavage site K627 in PB2 characterize this virus as highly pathogenic. This data was confirmed by direct pathogenic tests IVPI 3.0 MLD50 l 4Logl0EID50. Also molecular analysis showed sensivity of the virus to adamantanes and neuraminidase inhibitors. Serological analysis showed wide crossreactivity of this virus with sera produced to H5N l HPAI viruses isolated earlier in South-East Asia. Mean time to death of infected .