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báo cáo hóa học: " Effects of glatiramer acetate on fatigue and days of absence from work in first-time treated relapsing-remitting multiple sclerosis"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí hóa học quốc tế đề tài : Effects of glatiramer acetate on fatigue and days of absence from work in first-time treated relapsing-remitting multiple sclerosis | BioMed Central Health and Quality of Life Outcomes Research Effects of glatiramer acetate on fatigue and days of absence from work in first-time treated relapsing-remitting multiple sclerosis Tjalf Ziemssen 1 Josef Hoffman2 Rainer Apfel2 and Simone Kern1 Address 1MS Center Neurological University Clinic Technical University of Dresden Dresden Germany and 2TEVA Germany Morfelden Germany Email Tjalf Ziemssen - Tjalf.Ziemssen@uniklinikum-dresden.de Josef Hoffman - Josef.Hoffmann@teva.de Rainer Apfel - Rainer.Apfel@teva.de Simone Kern - Simone.Kern@uniklinikum-dresden.de Corresponding author Open Access Published 5 September 2008 Received 16 May 2008 II.LL ._J . J . .mr. A. AAAA 1 1 I IA I A r A r 1 Accepted 5 September 2008 Health and Quality of Life Outcomes 2008 6 67 doi l0.ll86 l477-7525-6-67 This article is available from http www.hqlo.cOm content 6 1 67 2008 Ziemssen et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Objectives Treatment of multiple sclerosis patients with glatiramer acetate has been demonstrated a beneficial effect on disease activity. The objective of this prospective naturalistic study was to evaluate the impact of glatiramer acetate on fatigue and work absenteeism. Methods 291 treatment-naive patients with relapsing remitting multiple sclerosis were included and treated with glatiramer acetate for twelve months. Relapse rates disability fatigue symptoms days of absence from work and adverse events were monitored. Fatigue was measured with the MFIS scale and with a visual analogue scale. Results Total MFIS scores decreased by 7.6 16.4 from 34.6 to 27.0 p 0.001 . Significant reductions were observed on all three subscales of the MFIS. Fatigue symptoms assessed using a visual analogue scale .