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Báo cáo sinh học: " The caveolae-mediated sv40 entry pathway bypasses the golgi complex en route to the endoplasmic reticulu"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: The caveolae-mediated sv40 entry pathway bypasses the golgi complex en route to the endoplasmic reticulu | Virology Journal BioMed Central Research Open Access The caveolae-mediated sv40 entry pathway bypasses the golgi complex en route to the endoplasmic reticulum Leonard C Norkin and Dmitry Kuksin Address Department of Microbiology University of Massachusetts - Amherst MA 01003 USA Email Leonard C Norkin - lnorkin@microbio.umass.edu Dmitry Kuksin - dkuksin@microbio.umass.edu Corresponding author Published 19 April 2005 Received 05 April 2005 Accepted 19 April 2005 Virology Journal 2005 2 38 doi 10.1 186 1743-422X-2-38 This article is available from http www.virologyj.cOm content 2 1 38 2005 Norkin and Kuksin licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Simian virus 40 SV40 enters cells via an atypical caveolae-mediated endocytic pathway which delivers the virus to a new intermediary compartment the caveosome. The virus then is believed to go directly from the caveosome to the endoplasmic reticulum. Cholera toxin likewise enters via caveolae and traffics to caveosomes. But in contrast to SV40 cholera toxin is transported from caveosomes to the endoplasmic reticulum via the Golgi. For that reason and because the caveosome and Golgi may have some common markers we revisited the issue of whether SV40 might access the endoplasmic reticulum via the Golgi. Results We confirmed our earlier finding that SV40 co localizes with the Golgi marker P-COP. However we show that the virus does not co localize with the more discriminating Golgi markers golgin 97 and BODIPY-ceramide. Conclusion The caveolae-mediated SV40 entry pathway does not intersect the Golgi. SV40 is seen to co localize with P-COP because that protein is a marker for caveosomes as well as the Golgi. Moreover these results are consistent with the .