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Báo cáo sinh học: " Intracellular localization of Crimean-Congo Hemorrhagic Fever (CCHF) virus glycoproteins"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Intracellular localization of Crimean-Congo Hemorrhagic Fever (CCHF) virus glycoproteins | Virology Journal BioMed Central Research Open Access Intracellular localization of Crimean-Congo Hemorrhagic Fever CCHF virus glycoproteins Sebastian Haferkamp1 2 3 Lisa Fernando2 4 Tino F Schwarz3 Heinz Feldmann2 4 and Ramon Flick 1 2 4 Address University of Texas Medical Branch Department of Pathology Center for Biodefense and Emerging Infectious Diseases 301 University Boulevard Galveston Texas 77555-0609 USA 2Special Pathogens Program National Microbiology Laboratory Health Canada CA-R3E 3R2 Winnipeg Canada 3Stiftung Juliusspital Wuerzburg 97070 Wuerzburg Germany and 4Department of Medical Microbiology University of Manitoba 543-730 William Avenue Winnipeg R3E 0W3 Canada Email Sebastian Haferkamp - basti.haferkamp@gmx.de Lisa Fernando - Lisa_Fernando@phac-aspc.gc.ca Tino F Schwarz - t.schwarz@juliusspital.de Heinz Feldmann - Heinz_Feldmann@phac-aspc.gc.ca Ramon Flick - raflick@utmb.edu Corresponding author Published 25 April 2005 Received 17 February 2005 Accepted 25 April 2005 Virology Journal 2005 2 42 doi l0.ll86 l 743-422X-2-42 This article is available from http www.virologyj.cOm content 2 1 42 2005 Haferkamp et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Crimean-Congo Hemorrhagic Fever virus CCHFV a member of the genus Nairovirus family Bunyaviridae is a tick-borne pathogen causing severe disease in humans. To better understand the CCHFV life cycle and explore potential intervention strategies we studied the biosynthesis and intracellular targeting of the glycoproteins which are encoded by the M genome segment. Results Following determination of the complete genome sequence of the CCHFV reference strain IbAr 10200 we generated expression plasmids for the individual expression of the .