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báo cáo hóa học: " Serum antibodies from Parkinson's disease patients react with neuronal membrane proteins from a mouse "

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Serum antibodies from Parkinson's disease patients react with neuronal membrane proteins from a mouse | Journal of Neuroinflammation BioMed Central Research Open Access Serum antibodies from Parkinson s disease patients react with neuronal membrane proteins from a mouse dopaminergic cell line and affect its dopamine expression Victor C Huber1 Tapan Mondal1 Stewart A Factor2 Richard F Seegal1 and David A Lawrence 1 Address Wadsworth Center New York State Department of Health Albany NY 12201 USA and 2Parkinson s Disease Movement Disorders Center Albany Medical College Albany NY 12208 USA Email Victor C Huber - victor.huber@stjude.org Tapan Mondal - tapanm02@yahoo.com Stewart A Factor - sfactor@emory.edu Richard F Seegal - seegal@wadsworth.org David A Lawrence - lawrencd@wadsworth.org Corresponding author Published 20 January 2006 Received 16 November 2005 Journal of Neuroinflammation 2006 3 1 doi l0.ll86 l 742-2094-3-1 Accepted 20 January 2006 This article is available from http www.jneuroinflammation.cOm content 3 1 1 2006 Huber et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Evidence exists suggesting that the immune system may contribute to the severity of idiopathic Parkinson s disease IPD . The data presented here demonstrates that antibodies in the sera of patients with IPD have increased binding affinity to dopaminergic DA neuronal MN9D cell line membrane antigens in comparison to antibodies in sera from healthy controls. In general the degree of antibody reactivity to these antigens of the mouse MN9D cell line appears to correlate well with the disease severity of the IPD patients contributing sera based on the total UPDRS scores. Surprisingly the sera from IPD patients enhanced the DA content of MN9D cells differentiated with n-butyrate the n-butyrate-differentiated MN9D cells had a greater concentration