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báo cáo hóa học: " Peripheral reductive capacity is associated with cognitive performance and survival in Alzheimer's disease"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Peripheral reductive capacity is associated with cognitive performance and survival in Alzheimer's disease | Journal of Neuroinflammation BioMed Central Research Open Access Peripheral reductive capacity is associated with cognitive performance and survival in Alzheimer s disease Luisa Minghetti 1 Anita Greco1 Maria Puopolo1 Marc Combrinck2 3 Donald Warden3 4 and A David Smith3 4 Address Department of Cell Biology and Neurosciences Section of Degenerative and Inflammatory Neurological Diseases Istituto Superiore di Sanità Viale Regina Elena 299 00161 Rome Italy 2Neurology Unit Department of Medicine University of Cape Town South Africa 3The Oxford Project to Investigate Memory and Ageing OPTIMA University Department of Pharmacology Radcliffe Infirmary Oxford UK and 4Oxford Centre for Gene Function University Department of Physiology Anatomy Genetics Parks Rd Oxford OX1 3PT UK Email Luisa Minghetti - luisa.minghetti@iss.it Anita Greco - agreco@iss.it Maria Puopolo - mpuopolo@iss.it Marc Combrinck - mcombrin@uctgsh1.uct.ac.za Donald Warden - donald.warden@pharmacology.oxford.ac.uk A David Smith - ad.smith@pharm.ox.ac.uk Corresponding author Published 03 March 2006 Received 10 February 2006 Accepted 03 March 2006 Journal of Neuroinflammation2006 3 4 doi l0.ll86 l742-2094-3-4 This article is available from http www.jneuroinflammation.cOm content 3 1 4 2006Minghetti et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Oxidative stress is believed to be an early event and a key factor in Alzheimer s disease AD pathogenesis and progression. In spite of an intensive search for surrogate markers to monitor changes related to oxidative stress in the brain there is as yet no consensus about which markers to use in clinical studies. The measurement of peripheral anti-oxidants is an alternative way of evaluating the .