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báo cáo hóa học: " Production of IL-16 correlates with CD4+ Th1 inflammation and phosphorylation of axonal cytoskeleton in multiple sclerosis lesions"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Production of IL-16 correlates with CD4+ Th1 inflammation and phosphorylation of axonal cytoskeleton in multiple sclerosis lesions | Journal of Neuroinflammation BioMed Central Research Open Access Production of IL-16 correlates with CD4 Thl inflammation and phosphorylation of axonal cytoskeleton in multiple sclerosis lesions Dusanka S Skundric 1 2 Juan Cai1 William W Cruikshank3 and Djordje Gveric4 Address Department of Neurology Wayne State University School of Medicine Detroit MI 48201 USA 2Department of Immunology and Microbiology Wayne State University School of Medicine Detroit MI 48201 USA 3Pulmonary Center Boston University School of Medicine Boston MA 02118 USA and 4Department of Neuroinflammation Institute of Neurology University College London WC1N 1PJ UK Email Dusanka S Skundric - skundric@cmb.biosci.wayne.edu Juan Cai - jcai@med.wayne.edu William W Cruikshank - bcruikshank@lung.bumc.bu.edu Djordje Gveric - dgueric@ion.ucl.ac.uk Corresponding author Published 26 May 2006 Received 07 April 2006 Journal of Neuroinflammation 2006 3 13 doi l0.ll86 1742-2094-3-13 Accepted 26 May 2006 This article is available from http www.jneuroinflammation.cOm content 3 1 1 3 2006 Skundric et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Multiple sclerosis MS is a central nervous system-specific autoimmune demyelinating and neurodegenerative disease. Infiltration of lesions by autoaggressive myelin-specific CD4 Th1 cells correlates with clinical manifestations of disease. The cytokine IL-16 is a CD4 T cell-specific chemoattractant that is biased towards CD4 Th1 cells. IL-16 precursor is constitutively expressed in lymphocytes and during CD4 T cell activation active caspase-3 cleaves and releases C-terminal bioactive IL-16. Previously we used an animal model of MS to demonstrate an important role for IL-16 in regulation of autoimmune .