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báo cáo hóa học: " Osteoarthritis accelerates and exacerbates Alzheimer’s disease pathology in mice"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Osteoarthritis accelerates and exacerbates Alzheimer’s disease pathology in mice | Kyrkanides et al. Journal of Neuroinflammation 2011 8 112 http www.jneuroinflammation.eom content 8 1 112 JJOURNAL1 OF. NEUROINFLAMMATION RESEARCH Open Access Osteoarthritis accelerates and exacerbates Alzheimer s disease pathology in mice Qi or ih nnc kX rl TỉniHoc D cc I I Ttỉ I lonfc4 lon-nio I I K iillor4 i l Ilr r E Olcr-tarvA L 4 5 DcifiCiCi IHncmn5 Siepiidnos f yikdiiiues Ross H Idiieius Jen Hie H Miiier Mdiiory E Oisciiovvkd Renee Joiinson Meixiang Yang 1 John A Oischowkd5 Sdbine M Brouxhon2 3 and M Kerry O Bdnion5 Abstract Background The purpose of this study wds to investigdte whether iocdiized peripherdi infidmmdtion such ds osteodrthritis contributes to neuroinfidmmdtion dnd neurodegenerdtive disedse in vivo. Methods We empioyed the inducibie Coi1-ILipXAT mouse modei of osteodrthritis in which induction of osteodrthritis in the knees dnd temporomdndibuidr joints resuited in dstrocyte dnd microgiidi dctivdtion in the brdin dccompdnied by upreguidtion of infidmmdtion-reidted gene expression. The bioiogicdi significdnce of the iink between peripherdi dnd brdin infidmmdtion wds expiored in the APP PS1 mouse modei of Aizheimer s disedse AD whereby osteodrthritis resuited in neuroinfidmmdtion ds weii ds exdcerbdtion dnd dcceierdtion of AD pdthoiogy. Results Induction of osteodrthritis exdcerbdted dnd dcceierdted the deveiopment of neuroinfidmmdtion ds dssessed by giidi ceii dctivdtion dnd qudntificdtion of infidmmdtion-reidted mRNAs ds weii ds Ab pdthoiogy dssessed by the number dnd size of dmyioid pidques in the APP PS1 Coi1-ILipXAT compound trdnsgenic mouse. Conclusion This work supports d modei by which peripherdi infidmmdtion triggers the deveiopment of neuroinfidmmdtion dnd subsequentiy the induction of AD pdthoiogy. Better understdnding of the iink between peripherdl locdlized infldmmdtion whether in the form of osteodrthritis dtherosclerosis or other conditions dnd brdin infldmmdtion mdy prove criticdl to our understdnding of the pdthophysiology of .