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báo cáo hóa học:" Effects of low power laser irradiation on bone healing in animals: a meta-analysis"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Effects of low power laser irradiation on bone healing in animals: a meta-analysis | Bashardoust Tajali et al. Journal of Orthopaedic Surgery and Research 2010 5 1 http www.josr-online.eom content 5 1 1 JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH REVIEW Open Access Effects of low power laser irradiation on bone healing in animals a meta-analysis Siamak Bashardoust Tajali1 Joy C MacDermid1 2 Pamela Houghton1 Ruby Grewal3 Abstract Purpose The meta-analysis was performed to identify animal research defining the effects of low power laser irradiation on biomechanical indicators of bone regeneration and the impact of dosage. Methods We searched five electronic databases MEDLINE EMBASE PubMed CINAHL and Cochrane Database of Randomised Clinical Trials for studies in the area of laser and bone healing published from 1966 to October 2008. Included studies had to investigate fracture healing in any animal model using any type of low power laser irradiation and use at least one quantitative biomechanical measures of bone strength. There were 880 abstracts related to the laser irradiation and bone issues healing surgery and assessment . Five studies met our inclusion criteria and were critically appraised by two raters independently using a structured tool designed for rating the quality of animal research studies. After full text review two articles were deemed ineligible for meta-analysis because of the type of injury method and biomechanical variables used leaving three studies for meta-analysis. Maximum bone tolerance force before the point of fracture during the biomechanical test 4 weeks after bone deficiency was our main biomechanical bone properties for the Meta analysis. Results Studies indicate that low power laser irradiation can enhance biomechanical properties of bone during fracture healing in animal models. Maximum bone tolerance was statistically improved following low level laser irradiation average random effect size 0.726 95 CI 0.08 - 1.37 p 0.028 . While conclusions are limited by the low number of studies there is concordance across .