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báo cáo hóa học:" Bone quality and growth characteristics of growth plates following limb transplantation between animals of different ages - Results of an experimental study in male syngeneic rats"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Bone quality and growth characteristics of growth plates following limb transplantation between animals of different ages - Results of an experimental study in male syngeneic rats | Modi et al. Journal of Orthopaedic Surgery and Research 2011 6 53 http www.josr-online.eom content 6 1 53 JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH RESEARCH ARTICLE Open Access Bone quality and growth characteristics of growth plates following limb transplantation between animals of different ages - Results of an experimental study in male syngeneic rats Hitesh N Modi Seung Woo Suh Boopalan Prjvc Jae-Young Hong Jae-Hyuk Yang Young-Hwan Park Jae-Moon Lee and Yong-Hyon Kwon Abstract Introduction The purpose of this study was to identify graft osteoporosis post transplantation by micro-CT analysis and the growth potential of growth plates in the transplanted limb. Methods Ten juvenile to juvenile and five juvenile to adult hind limb transplants were performed in male syngeneic Lewis rats. Upper tibial bone density in isochronograft and heterochronograft limbs was measured by 3D micro-CT and compared with that of the opposite non-operated limbs. Results We observed inferior bone quality p 0.05 in heterochronografts compared to isochronografts. After transplantation isochronografts did not exhibit increases in tibial lengths compared to opposite juvenile nonoperated tibias p 0.66 or heterochronograft tibias p 0.61 . However significant differences were observed between heterochrongraft tibial lengths when and opposite adult non operated tibial lengths p 0.001 . Conclusions Age dependent alterations affect bone quality resulting in post transplantation osteoporosis in heterochronografts but not isochronografts. However the growth plates of transplanted limbs retain their properties of longitudinal growth and continue to grow at the same rate. Keywords Limb transplant isochronografts heterochronografts osteoporosis growth potentials of growth plate Background Osteoporosis often develops in transplanted and grafted bone after bone transplantation or grafting 1-4 due to revascularization and creeping substitution that occur during the repair process. Kline et al. 1 .