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báo cáo hóa học:" Evaluating preference weights for the Asthma Symptom Utility Index (ASUI) across countries"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Evaluating preference weights for the Asthma Symptom Utility Index (ASUI) across countries | BioMed Central Health and Quality of Life Outcomes Research Evaluating preference weights for the Asthma Symptom Utility Index ASUI across countries Emuella M Flood1 Erwin De Cock1 Ann-Christin Mork2 and Dennis A Revicki 1 Open Access Address 1Center for Health Outcomes Research United BioSource Corporation Bethesda MD United States London UK and 2Formerly of AstraZeneca Lund Sweden Email Emuella M Flood - emuella.flood@unitedbiosource.com Erwin De Cock - erwin.decock@unitedbiosource.com Ann- Christin Mork - ann-christin.mork@pfizer.com Dennis A Revicki - dennis.revicki@unitedbiosource.com Corresponding author Published 15 August 2006 Received 13 June 2006 Health and Quality of Life Outcomes 2006 4 51 doi 10.1186 1477-7525-4-51 Accepted 15 August 2006 This article is available from http www.hqlo.cOm content 4 1 51 2006 Flood et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The Asthma Symptom Utility Index ASUI is a preference-based outcome measure used in US clinical trials and cost-effectiveness studies for asthma. This study evaluated ASUI preference weights in Europe to determine whether the multi-attribute utility function based on preferences from a US population is generalizable across countries. Methods Data were collected from ninety asthma patients from Italy France and the United Kingdom using the Asthma Control Questionnaire the Asthma Quality of Life Questionnaire and the ASUI. Subjects rated their preferences for 10 asthma health states using a visual analogue scale VAS and a standard gamble SG interview. Results All multi-symptom states showed statistically significant differences p 0.001 between countries in mean VAS scores. Mean SG utility scores between the US and France and the US