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Báo cáo hóa học: " Effects of paraoxonase activity and gene polymorphism on coronary vasomotion"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí hóa hoc quốc tế đề tài : Effects of paraoxonase activity and gene polymorphism on coronary vasomotion | Dunet et al. EJNMMI Research 2011 1 27 http www.ejnmmires.eom content 1 1 27 9 EJNMMI Research a SpringerOpen Journal ORIGINAL RESEARCH Open Access Effects of paraoxonase activity and gene polymorphism on coronary vasomotion 12 12 3 1 Vincent Dunet Juan Ruiz Gilles Allenbach Paola Izzo Richard W James and John O Prior Abstract Background Paraoxonase 1 PON1 is recognized as a protective enzyme against LDL oxidation and PON1 polymorphism has been described as a factor influencing coronary heart disease CHD free survival. As coronary vasoreactivity is a surrogate of future cardiovascular events we aimed at assessing the respective effect of the PON1 genotype and activity on coronary vasoreactivity in a population of type 2 diabetic patients. Methods Nineteen patients with type 2 diabetes mellitus underwent 82Rb cardiac PET CT to quantify myocardial blood flow MBF at rest during cold pressor testing CPT and during adenosine-induced hyperaemia to compute myocardial flow reserve MFR . They were allocated according to Q192R and L55M polymorphisms into three groups wild-type and LM QR heterozygotes MM homozygotes and RR homozygotes and underwent a measurement of plasmatic PON1 activity. Relations between rest-MBF stress-MBF MFR and MBF response to CPT and PON1 genotypes and PON1 activity were assessed using Spearman s correlation and multivariate linear regression analysis. Results Although PON1 activity was significantly associated with PON1 polymorphism p 0.0001 there was no significant relation between the PON1 genotypes and the rest-MBF stress-MBF or MBF response to CPT p 0.33 . The PON1 activity significantly correlated with the HDL plasma level p 0.63 p 0.005 age p -0.52 p 0.027 and MFR p 0.48 p 0.044 . Moreover on multivariate analysis PON1 activity was independently associated with MFR p 0.037 . Conclusion Our study supports an independent association between PON1 activity and MFR. Whether PON1 contributes to promote coronary vasoreactivity through its antioxidant