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Báo cáo hóa học: " On the Enhanced Antibacterial Activity of Antibiotics Mixed with Gold Nanoparticles"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: On the Enhanced Antibacterial Activity of Antibiotics Mixed with Gold Nanoparticles | Nanoscale Res Lett 2009 4 794-801 DOI 10.1007 s11671-009-9316-8 NANO EXPRESS On the Enhanced Antibacterial Activity of Antibiotics Mixed with Gold Nanoparticles G. L. Burygin B. N. Khlebtsov A. N. Shantrokha L. A. Dykman V. A. Bogatyrev N. G. Khlebtsov Received 17 December 2008 Accepted 6 April 2009 Published online 21 April 2009 to the authors 2009 Abstract The bacterial action of gentamicin and that of a mixture of gentamicin and 15-nm colloidal-gold particles on Escherichia coll K12 was examined by the agar-well-diffusion method enumeration of colony-forming units and turbidimetry. Addition of gentamicin to colloidal gold changed the gold color and extinction spectrum. Within the experimental errors there were no significant differences in antibacterial activity between pure gentamicin and its mixture with gold nanoparticles NPs . Atomic absorption spectroscopy showed that upon application of the gentami-cin-particle mixture there were no gold NPs in the zone of bacterial-growth suppression in agar. Yet free NPs diffused into the agar. These facts are in conflict with the earlier findings indicating an enhancement of the bacterial activity of similar gentamicin-gold nanoparticle mixtures. The possible causes for these discrepancies are discussed and the suggestion is made that a necessary condition for enhancement of antibacterial activity is the preparation of stable conjugates of NPs coated with the antibiotic molecules. Keywords Colloidal-gold nanoparticles Gentamicin Drug delivery Antibacterial activity Agar-well-diffusion method Minimum inhibitory concentration G. L. Burygin B. N. Khlebtsov L. A. Dykman V. A. Bogatyrev N. G. Khlebtsov El Institute of Biochemistry and Physiology of Plants and Microorganisms Russian Academy of Sciences 13 Prospekt Entuziastov 410049 Saratov Russia e-mail khlebtsov@ibppm.sgu.ru G. L. Burygin A. N. Shantrokha V. A. Bogatyrev N. G. Khlebtsov Saratov State University 83 Ulitsa Astrakhanskaya 410026 Saratov Russia Maximum tolerant