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Amyotrophic Lateral Sclerosis Part 3

Tham khảo tài liệu 'amyotrophic lateral sclerosis part 3', khoa học tự nhiên, công nghệ sinh học phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | 62 Amyotrophic Lateral Sclerosis time is introduced explicitly. Therefore dynamic meta-analysis can incorporate experimental data from differing time-points and predict effects over time. These traits make dynamic meta-analysis unique even when compared to advanced meta-analysis methods such as network analysis Trelle Reichenbach et al. 2011 . while network analysis does use comparative relationships it does not include interactions or show how relationship ratios change over time. Thus where traditional or even advanced metaanalysis produces a static set of linear relationships dynamic meta-analysis produces a set of differential equations. This results in an innovative way to examine pathology dynamics as we can look at how metrics change and interact over time rather than being limited to how they correlate at a single point in time. Currently the only other available technique capable of implictly including interactions and explicity including time is relational modeling Mitchell 2009 Mitchell and Lee 2008 . In fact dynamic meta-analysis is itself one form of relational modeling. However traditional relational models typically do not provide the desired statistical weight of dynamic meta-analysis since only one primary study is included per interaction. 2.3 Overview of the dynamic meta-analysis process Dynamic meta-analysis is similar to traditional meta-analysis in that it utilizes literature searches inclusion exclusion critieria and data aggregation techniques. A key difference in the dynamic meta-analysis process however is the study structure and data extraction. In the following sub-sections of the chapter we provide the details necessary to perform each step of dynamic meta-analysis determining the study scope performing literature searches and study inclusion excusion developing structure extracting data aggregating extracted data implementing dynamic meta-analysis and analyzing dynamic meta-analysis results. 2.4 Defining the study scope Just as in .