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Báo cáo khoa học: A highly active adipyl-cephalosporin acylase obtained via rational randomization

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There is strong interest in creating an enzyme that can deacylate natural cephalosporins such as cephalosporin C in order to efficiently acquire the starting compound for the industrial production of semisynthetic cephalo-sporin antibiotics. In this study, the active site of the glutaryl acylase from PseudomonasSY-77 was randomized rationally.

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