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Báo cáo khoa học: A peptide containing a novel FPGN CD40-binding sequence enhances adenoviral infection of murine and human dendritic cells

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CD40 is areceptorwithnumerous functions in theactivation of antigenpresentingcells (APCs), particularlydendritic cells (DC). Using phage display technology, we identified linear peptides containing a novel FPGN/S consensus sequence that enhances the binding of phage to a purified murine CD40-immunoglobulin (Ig) fusion protein (CD40-Ig), but not to Ig alone. To examine the ability theFPGN/Speptides to enhance adenoviral infection of CD40-positive cells, we used bifunctional peptides consisting of an FPGN-contain-ing peptide covalently linked to an adenoviral knob-binding peptide (KBP)

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