Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Inducibility of the endogenous antibiotic peptide β-defensin 2 is impaired in patients with severe sepsis. | Available online http content 11 1 R19 Open Access Research Inducibility of the endogenous antibiotic peptide p-defensin 2 is impaired in patients with severe sepsis Malte Book1 QiXing Chen1 2 Lutz E Lehmann1 Sven Klaschik1 Stefan Weber1 Jens- Christian Schewe1 Markus Luepertz1 Andreas Hoeft1 and Frank Stuber1 Department of Anaesthesiology and Intensive Care Medicine Rheinische-Friedrich-Wilhelms University Bonn Sigmund-Freud-Str. 25 53105 Bonn Germany 2Department of Anaesthesiology School of Medicine Zhejiang University 388 Yuhang Tang Road 310058 Hangzhou People s Republic of China Corresponding author Malte Book Received 31 Jul 2006 Revisions requested 1 Sep 2006 Revisions received 8 Jan 2007 Accepted 15 Feb 2007 Published 15 Feb 2007 Critical Care 2007 11 R19 doi cc5694 This article is online at http content 11 1 R19 2007 Book et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction The potent endogenous antimicrobial peptide human p-defensin 2 hBD2 is a crucial mediator of innate immunity. In addition to direct antimicrobial properties different effects on immune cells have been described. In contrast to the well-documented epithelial p-defensin actions in local infections little is known about the leukocyte-released hBD2 in systemic infectious disorders. This study investigated the basic expression levels and the ex vivo inducibility of hBD2 mRNA in peripheral whole blood cells from patients with severe sepsis in comparison to non-septic critically ill patients and healthy individuals. Methods This investigation was a prospective case-control study performed at a surgical intensive care unit at a university hospital. A total of 34 .
