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Lecture Genetics: From genes to genomes - Chapter 8: Gene expression: The flow of information from DNA to RNA to protein

Chapter 8 includes contents: The genetic code, transcription: from DNA to RNA, translation: from mRNA to protein, differences in gene expression between prokaryotes and eukaryotes, a comprehensive example: computerized analysis of gene expression in C. elegans, The effect of mutations on gene expression and gene function. | Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display PowerPoint to accompany Genetics: From Genes to Genomes Fourth Edition Leland H. Hartwell, Leroy Hood, Michael L. Goldberg, Ann E. Reynolds, and Lee M. Silver Prepared by Mary A. Bedell University of Georgia CHAPTER What Genes Are and What They Do CHAPTER PART II CHAPTER OUTLINE Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display Hartwell et al., 4th edition, Chapter 8 Gene Expression: The Flow of Information from DNA to RNA to Protein 8.1 The Genetic Code 8.2 Transcription: From DNA to RNA 8.3 Translation: From mRNA to Protein 8.4 Differences in Gene Expression Between Prokaryotes and Eukaryotes 8.5 A Comprehensive Example: Computerized Analysis of Gene Expression in C. elegans 8.6 The Effect of Mutations on Gene Expression and Gene Function Four general themes for gene expression Pairing of complementary bases is the key to the transfer of information from DNA to RNA and from RNA to protein Polarities of DNA, RNA, and polypeptides help guide the mechanisms of gene expression Gene expression requires input of energy and participation of specific proteins and macromolecular assemblies Mutations that change genetic information or obstruct the flow of its expression can have dramatic effects on phenotype Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display Hartwell et al., 4th edition, Chapter 8 Gene expression: the flow of genetic information from DNA via RNA to protein RNA polymerase transcribes DNA to produce an RNA transcript Ribosomes translate the mRNA sequence to synthesize a polypeptide Translation follows the "genetic code" Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display Hartwell et al., 4th edition, Chapter 8 Fig. 8.2 Triplet codons of nucleotides represent individual amino acids 61 codons represent the 20 amino acids 3 codons . | Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display PowerPoint to accompany Genetics: From Genes to Genomes Fourth Edition Leland H. Hartwell, Leroy Hood, Michael L. Goldberg, Ann E. Reynolds, and Lee M. Silver Prepared by Mary A. Bedell University of Georgia CHAPTER What Genes Are and What They Do CHAPTER PART II CHAPTER OUTLINE Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display Hartwell et al., 4th edition, Chapter 8 Gene Expression: The Flow of Information from DNA to RNA to Protein 8.1 The Genetic Code 8.2 Transcription: From DNA to RNA 8.3 Translation: From mRNA to Protein 8.4 Differences in Gene Expression Between Prokaryotes and Eukaryotes 8.5 A Comprehensive Example: Computerized Analysis of Gene Expression in C. elegans 8.6 The Effect of Mutations on Gene Expression and Gene Function Four general themes for gene expression Pairing of complementary bases is the key to the transfer of .