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Một số hợp chất từ hoa Cây sơn cúc ba thùy Wedelia trilobata (l.) hitch., họ Cúc (Asteraceae)

Cây Sơn cúc ba thùy, Wedelia trilobata Hitch., chưa được nghiên cứu nhiều trên thế giới cũng như ở Việt Nam. Từ hoa cây Sơn cúc ba thùy, mười hợp chất đã được cô lập: friedelan-3β-ol (hoặc epifriedelanol) (1), erythrodiol (2), 28-hydroxy-3β-tetradecanoyloxyolean-12-en (hoặc 3β-tetradecanoyloxyerythrodiol) (3), acid 3β-henicosanoyloxyolean-12-en-28-oic (4), 3β-pentadecanoyloxyolean-28(13)-lacton (5), acid kaura-9(11),16-dien-18-oic (hoặc acid grandiflorenic) (6), 2-(3-hydroxy-3,7,11,15-tetrametylhexadecyl)-3,5,6-trimetyl-1,4-dihydroxybenzen (hoặc tocopherolhydroquinon) (7), gramisterol (8), stigmasterol (9) and b-sitosterol 3-O-b-D-glucopyranosid (10). Cấu trúc của những hợp chất này được xác định dựa trên dữ liệu phổ NMR và kết hợp với so sánh tài liệu tham khảo. | Science & Technology Development, Vol 14, No.T2- 2011 SOME COMPOUNDS FROM FLOWER OF WEDELIA TRILOBATA (L.) HITCH. (ASTERACEAE) Truong Thi Hong Nguyet, Nguyen Thi Hoai Thu, Ton That Quang, Nguyen Kim Phi Phung University of Science, VNU HCM (Manuscript Received on January 24th 2011, Manuscript Revised October 25th, 2011) ABSTRACT: Wedelia trilobata Hitch. has not much been chemically and biologically studied. From the flower of Wedelia trilobata, ten compounds were isolated: friedelan-3β-ol (or epifriedelanol) (1), erythrodiol (2), 28-hydroxy-3β -tetradecanoyloxyolean-12-ene (or 3β -tetradecanoyloxyerythrodiol) (3), 3β-henicosanoyloxyolean-12-en-28-oic acid (4), 3β-pentadecanoyloxyolean-28(13)-lactone (5), kaura-9(11),16-dien-18-oic acid (or grandiflorenic tetramethylhexadecyl)-3,5,6-trimethyl-1,4-dihydroxybenzene acid) (or (6), 2-(3-hydroxy-3,7,11,15- tocopherolhydroquinone) (7), gramisterol (8), stigmasterol (9) and β-sitosterol 3-O-β-D-glucopyranoside (10). The structures of these compounds were determined through the interpretation of their NMR data and compared with references. Key words: Asteraceae, Wedelia trilobata, triterpenoids, diterpenoids, sterols. INTRODUCTION Wedelia trilobata Hitch. is a plant of Asteraceae family that wildly grows in many areas in Vietnam. This herb was used as folk Trang 20 remedy for haemostatic, treating diarrhea, snake bite, wound, ect.[1] Moreover, its flowers have not much biologically studied, been chemically therefore and they were chosen to study. In this paper, we report the TAÏP CHÍ PHAÙT TRIEÅN KH&CN, TAÄP 14, SOÁ T2 - 2011 isolation and structural determination of ten compounds: friedelan-3β-ol (or epifriedelanol) (1), erythrodiol (2), 28-hydroxy-3β- Extraction and isolation Fresh flower (10.3 kg) was washed, dried, ground into powder (950g) and extracted by tetradecanoyloxyolean-12-ene (or 3β- maceration with ethanol at room temperature tetradecanoyloxyerythrodiol) (3), 3β- then the