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Chemical constituents from the mycelium of isaria japonica yasuda

A chemical investigation of the mycelium of Isaria japnonica Yasuda resulted in the identification of eight compounds, including two steroids (ergosterol, ergosterol peroxide), one flavonoid (tricine), one phenolic (2-hydroxy-3-phenylpropanoic acid), two nitrogenous compounds (adenosine, uracil), one saccharide (D-mannitol), one amino acid (3-amino butanoic acid). The chemical structures of nine compounds were determined on the basis of 1D and 2D NMR, UV, IR and MS analytical results. | Journal of Science and Technology 54 (2C) (2016) 334-340 CHEMICAL CONSTITUENTS FROM THE MYCELIUM OF ISARIA JAPONICA YASUDA Nguyen Ngoc Tuan, Nguyen Tan Thanh, Dao Thi Thanh Xuan, Tran Dinh Thang * Department of Chemistry, Vinh University, 182 Le Duan, Vinh City, Nghe An province, Vietnam * Email: thangtd@vinhuni.edu.vn Received: 15 June 2016; Accepted for publication: 23 October 2016 ABSTRACT A chemical investigation of the mycelium of Isaria japnonica Yasuda resulted in the identification of eight compounds, including two steroids (ergosterol, ergosterol peroxide), one flavonoid (tricine), one phenolic (2-hydroxy-3-phenylpropanoic acid), two nitrogenous compounds (adenosine, uracil), one saccharide (D-mannitol), one amino acid (3-amino butanoic acid). The chemical structures of nine compounds were determined on the basis of 1D and 2D NMR, UV, IR and MS analytical results. Keywords: Isaria japnonica, triterpenoid, steroid, flavonoid, phenolic. 1. INTRODUCTION Natural remedies are becoming increasingly popular and important in the public and scientific communities. Historically, natural remedies have been shown to present interesting biological and pharmacological activity and are used as chemotherapeutic agents. For centuries Cordyceps is a genus of more than 400 species in the family Clavicipitaceae. All Cordyceps species are endoparasitoids, parasitic mainly on insects and other arthropods, a few are parasitic on other fungi. Until recently, the best known species of the genus was Cordyceps sinensis [1, 2, 3]. Isaria japonica Yasuda has traditionally been used as health foods for various diseases in Japan, Korea and China [2, 3, 5]. Myriocin, a sphingosine analog isolated from the culture filtrate of Isaria sinclairii (P. cicadae), showed inhibitory effect on T cell-dependent immune responses [5]. Recently, they reported about the success in cultivating I. japonica (P. tenuipes) in a liquid medium and demonstrated that this liquid medium augmented anti-sheep .