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Anticancer agents from natural products 2

Part 2 book “Anticancer agents from natural products” has contents: The actinomycins, benzoquinone ansamycins, bleomycin group antitumor agents, the mitomycins, staurosporines and structurally related indolocarbazoles as antitumor agents, combinatorial biosynthesis of anticancer natural products, developments and future trends in anticancer natural products drug discovery, and other contents. | 15 The Actinomycins* Anthony B. Mauger and Helmut Lackner† CONTENTS 15.1 15.2 15.3 15.4 15.5 15.6 15.7 15.8 15.9 Historical Introduction 363 Separation and Nomenclature364 Structures. 365 Conformation. 366 Mechanism of Biological Action. 366 In Vitro Antitumor Activity. 368 In Vivo Antitumor Activity and Toxicity. 368 Synthesis 368 Analogs 369 15.9.1 Directed Biosynthesis 369 15.9.2 Partial Synthesis 369 15.9.3 Total Synthesis. 370 15.10 Structure–Activity Relationships. 371 15.10.1 Introduction. 371 15.10.2 Natural Actinomycin .