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Preliminary studies on antiin!ammatory, antipyretic, and antidiarrhoeal properties of Evolvulus alsinoides

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The ethanolic extract of the whole plant of Evolvulus alsinoides L. (Convolvulaceae) was investigated for anti inflammatory, antipyretic and antidiarrheal properties in female albino rats. | Turk J Biol 35 (2011) 611-618 © TÜBİTAK doi:10.3906/biy-0904-19 Preliminary studies on antiinflammatory, antipyretic, and antidiarrhoeal properties of Evolvulus alsinoides U. M. Dhana LEKSHMI, P. Neelakanta REDDY Bio Organic Chemistry Laboratory, Central Leather Research Institute, (Council of Scientific and Industrial Research) Adyar, Chennai -600020 - INDIA Received: 27.04.2009 Abstract: e ethanolic extract of the whole plant of Evolvulus alsinoides L. (Convolvulaceae) was investigated for antiinflammatory, antipyretic and antidiarrhoeal properties in female albino rats. Preliminary phytochemical studies were carried out to confirm the presence of active chemical constituents in the plant extract, and the result showed a positive report for the presence of flavonoids, alkaloids and cardiac glycosides. e pharmacological result showed that the ethanolic extract at a dose of 250 mg/kg body weight and 500 mg/kg body weight caused a significant (P < 0.05) inhibition of the carrageenan-induced rat paw oedema and a significant (P < 0.05) reduction of hyperpyrexia induced by Brewer’s yeast in rats. e extract also elicited marked antidiarrhoeal activity against castor oil-induced diarrhoea at a dose of 500 mg/kg. is study has proved scientifically the ancient claim that the whole plant of Evolvulus alsinoides has antiinflammatory, antipyretic and antidiarrhoeal activities. Key words: Evolvulus alsinoides, antiinflammatory, antipyretic, antidiarrhoeal, rats, carrageenan, brewer’s yeast, castor oil Evolvulus alsinoides’un antiinflamatuar, antipiretik ve antidiyare özellikleri üzerine ön çalışmalar Özet: Evolvulus alsinoides L. (Convolvulaceae) tüm bitkisinin etanolik özütü, dişi albino sıçanlarda antiinflamatuar, antipiretik ve antidiyare özellikleri bakımından araştırıldı. Bitki özütündeki aktif kimyasal bileşenlerinin varlığını doğrulamak için ön fitokimyasal çalışmalar yapıldı ve sonuç flavonoidlerin, alkaloidlerin ve kardiyak glikozitlerin varlığına dair olumlu

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Preliminary studies on antiin!ammatory, antipyretic, and antidiarrhoeal properties of Evolvulus alsinoides
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