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Effects of the introduction of zoledronate on the structure, dissolution and bioactivity of bioglass composite - MAS-NMR and ICP-OES investigations

In this study, two physical-chemical methods MAS-NMR (Magic angle spinning – nuclear magnetic resonance) and ICP-OES (Inductively coupled plasma – optical emission spectrometry) were used to clarify the effect of the introduction of zoledronate on the structure, dissolution and bioactivity of BG. The obtained results showed that the introduction of 0.1 wt.% of zoledronate modified the structural network, slowed down the dissolution and stimulated the bioactivity of bioglass. | VNU Journal of Science: Natural Sciences and Technology, Vol. 34, No. 4 (2018) 16-20 Effects of the Introduction of Zoledronate on the Structure, Dissolution and Bioactivity of Bioglass Composite MAS-NMR and ICP-OES Investigations Bui Xuan Vuong* Sai Gon University, 273 An Duong Vuong, District. 5, Ho Chi Minh City Received 12 November 2018 Revised 19 December 2018; Accepted 25 December 2018 Abstract: Biocomposite of bioglass (BG) with 0.1 wt.% of zoledronate (Z) has been elaborated for medical applications as reported in the previous study [1]. The synthetic material has been proven to be bioactive. In this study, two physical-chemical methods MAS-NMR (Magic angle spinning – nuclear magnetic resonance) and ICP-OES (Inductively coupled plasma – optical emission spectrometry) were used to clarify the effect of the introduction of zoledronate on the structure, dissolution and bioactivity of BG. The obtained results showed that the introduction of 0.1 wt.% of zoledronate modified the structural network, slowed down the dissolution and stimulated the bioactivity of bioglass. Keywords: Bioglass, zoledronate, composite, lyophilization, in vitro, bioactivity. 1. Introduction on their surface during in vitro and in vivo experiments. The resulting apatite layer permits an intimate bone-bonding between the artificial implant and the host tissue [2-4]. Bisphosphonates (BPs) are a class of compounds that are widely used to treat some diseases related to bone loss (such as osteoporosis), Paget’s disease, fibrous dysplasia, myeloma and bone metastases [5-6]. Bisphosphonates are stable analogues of inorganic pyrophosphate, a naturally occurring Bioactive glasses (bioglasses - BG) are a group of surface-active ceramic materials used for artificial implants in human body to repair and replace diseased or damaged bones. The main composition of bioglasses consists of SiO2, CaO, Na2O and P2O5 oxides in which these oxides do not exist independently but bond together to form a 3D