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Effects of long-term exposure of female rats to low levels of lead: ovary and uterus histological architecture changes

The aim of the current study was to evaluate lead accumulation in the ovaries, fallopian tubes, and uterus and to take note of any consequent histo-architectural changes. The experiment involved a 12-month chronic exposure of 28 Wistar female rats at sexual maturity (221 ± 0.88 g/individual) to lead acetate in drinking water. | Turkish Journal of Biology Turk J Biol (2015) 39: 284-289 © TÜBİTAK doi:10.3906/biy-1407-6 http://journals.tubitak.gov.tr/biology/ Research Article Effects of long-term exposure of female rats to low levels of lead: ovary and uterus histological architecture changes 1 2 3 4 5 1 Eugenia DUMITRESCU , Viorica CHIURCIU , Florin MUSELIN , Roxana POPESCU , Diana BREZOVAN , Romeo T. CRISTINA 1 Pharmacology and Pharmacy Departments, Faculty of Veterinary Medicine, Banat’s University of Agriculture and Veterinary Medicine “King Michael I of Romania”, Timisoara, Romania 2 Drugs Production Department, Romvac Company, Voluntari, Romania 3 Veterinary Toxicology Department, Faculty of Veterinary Medicine, Banat’s University of Agriculture and Veterinary Medicine “King Michael I of Romania”, Timisoara, Romania 4 Cellular and Molecular Biology Department, University of Medicine and Pharmacy “Victor Babes”, Timisoara, Romania 5 Histology and Molecular Biology Department, Faculty of Veterinary Medicine, Banat’s University of Agriculture and Veterinary Medicine “King Michael I of Romania”, Timisoara, Romania Received: 02.07.2014 Accepted: 10.09.2014 Published Online: 01.04.2015 Printed: 30.04.2015 Abstract: The aim of the current study was to evaluate lead accumulation in the ovaries, fallopian tubes, and uterus and to take note of any consequent histo-architectural changes. The experiment involved a 12-month chronic exposure of 28 Wistar female rats at sexual maturity (221 ± 0.88 g/individual) to lead acetate in drinking water. The rats were divided into 4 groups based on the level of lead exposure: E1 at 0.050 mg L–1, E2 at 0.100 mg L–1, E3 at 0.150 mg L–1 , and a control group that received tap water. Lead level evaluation was performed by atomic absorption spectrometry at 283.3 nm and the histo-architectonics in target organs were evaluated after hematoxylin and eosin staining and microscopy. The exposure to lead acetate produced significant histological alterations