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Efficacy of antibiotic regimens used at severe burn patients

Objectives: To conduct efficacy trials of various antibiotic regimens that had been used at the Intensive Care Unit, National Institute of Burns. Subjects and methods: A retrospective study was conducted on 101 medical records of severe burn patients admitted to the Intensive Care Unit, National Institute of Burns. | Journal of military pharmaco-medicine EFFICACY OF ANTIBIOTIC REGIMENS USED IN SEVERE BURN PATIENTS Nguyen Thi Hong Tham*; Luong Quang Anh* Nguyen Nhu Lam*; Nguyen Gia Tien SUMMARY Objectives: To conduct efficacy trials of various antibiotic regimens that had been used at the Intensive Care Unit, National Institute of Burns. Subjects and methods: A retrospective study was conducted on 101 medical records of severe burn patients admitted to the Intensive Care Unit, National Institute of Burns. The data were analysed by calculating and comparing the outcomes among three antibiotic regimens. Results: The prophylactic-antibiotic regimens succeeced in 17.56% of cases. Among the antibiotic regimens, the combination between cephalosporin and fosfomycin had 19.23% of successful cases. The replaced-antibiotic regimens succeeded in 50% of patients with majority of two-antibiotic regimens (68.49%). Among two-antibiotic regimens, the combination between carbapenem and other antibiotics was predominant (54.84%). Conclusions: Effectiveness of different antibiotic regimens was different for severe burn patients. Further research should be conducted to clarify the indications and effects of antibiotics for severe burn patients. * Keywords: Severe burn; Antibiotic regimen; Effectiveness. INTRODUCTION Treatment of severe-burn patients still has encountered challenges because of complication, especially multi-organ dysfunction, sepsis [4, 5, 6]. Antibiotics are currently prescribed for prevention as well as treatment of infection post burn. However, two subsequence problems including inappropriate antibiotics and uneffectiveness can affect the efficacy of antibiotics. The aim of this study is: To evaluate the efficacy of several antibiotic regimens using in severe-burn patients at Intensive Care Unit, National Institute of Burns. SUBJECTS AND METHODS 1. Subjects. Medical records of 101 patients with severe burn treated at the Intensive Care Unit, National Institute of Burns from 01