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Survey on the relationship between serum concentration of iron, ferritin and some characterisitics in patients with stage 3 to 5 chronic predialysis kidney disease

Objectives: To evaluate the relationship between serum iron and ferritin concentrations with some characteristics of chronic kidney diseases. Subjects and methods: A cross-sectional study with a study group of 124 stage 3 - 5 chronic kidney disease patients, and a control group of 66 healthy people at Department of Nephrology and Hemodialysis, 103 Military Hospital. | Journal of military pharmaco-medicine n09-2018 SURVEY ON THE RELATIONSHIP BETWEEN SERUM CONCENTRATION OF IRON, FERRITIN AND SOME CHARACTERISITICS IN PATIENTS WITH STAGE 3 TO 5 CHRONIC PREDIALYSIS KIDNEY DISEASE Nguyen Van Hung1, Nguyen Cao Luan2; Le Viet Thang3 SUMMARY Objectives: To evaluate the relationship between serum iron and ferritin concentrations with some characteristics of chronic kidney diseases. Subjects and methods: A cross-sectional study with a study group of 124 stage 3 - 5 chronic kidney disease patients, and a control group of 66 healthy people at Department of Nephrology and Hemodialysis, 103 Military Hospital. Results: The mean concentrations of serum iron in study group was significantly lower than control group (10.7 µmol/L versus 15.81 µmol/L), but the mean concentrations of serum ferritin in study group was higher than control group (403.73 ng/mL versus 198.45 ng/mL) with p 5 mg/L: diagnosed as increase. * Statistical analysis: Statistical analyses were conducted using SPSS 20.0. 115 Journal of military pharmaco-medicine n09-2018 RESULTS The study group with average age was 52.65 years old, there were 72.6% male; 27.4% female, mean glomerular filtration rate was 8.3 mL/min. Table 2: Iron and ferritin concentrations between study group and control group. Indexes Control group (n = 66) Study group (n = 124) p Median 15.81 (11.56 - 19.26) 10.7 (6.62 - 15.25) 0.05 0.05). Table 4: Correlation between serum iron, ferritin concentrations and serum creatinine (n = 124). Indexes Creatinine (µmoL/L) Correlation equation r p Iron (µmoL/L) 0.201 0.05 - Serum iron concentration was positively correlated with serum creatinine concentration (r = 0.201, p 0.05). 116 Journal of military pharmaco-medicine n09-2018 Chart 1: Correlation between serum iron concentration and serum creatinine. Table 5: Relation between serum iron, ferritin concentrations and hs-CRP (n = 112). hs-CRP status hs-CRP > 5 mg/L (n = 48) hs-CRP ≤ 5 mg/L (n =