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Deficiency of ADAMTS-13 in pediatric patients with severe sepsis and impact on in-hospital mortality

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The enzyme involved in regulating the size of vWF (von Willebrand factor) in plasma is ADAMTS-13 (A disintegrin and metalloprotease with thrombospondin type-1 motives). Deficient proteolysis of ULvWF (ultra large von Willebrand factor) due to reduced ADAMTS-13 activity results in disseminated platelet-rich thrombi in the microcirculation characteristic of thrombotic thrombocytopenic purpura. | Deficiency of ADAMTS-13 in pediatric patients with severe sepsis and impact on in-hospital mortality

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