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Antidiabetic and antilipidemic effect of Khaya senegalensis ethanolic bark extract in alloxan induced diabetic wistar rats

This study investigated the anti-diabetic effect of ethanolic bark extract of Khaya senegalensis in Alloxan-induced diabetic albino Wistar rats. Sixty (60) female albino rats were randomly placed into six (6) study groups of ten (10) animals designated as; nondiabetic control (NDC), diabetic control (DC), and diabetic extract treated groups (DSB1, DSB2, and DSB3) receiving varying extract concentration of 100mg/kg, 200mg/kg, and 400mg/kg body weight respectively. | Antidiabetic and antilipidemic effect of Khaya senegalensis ethanolic bark extract in alloxan induced diabetic wistar rats Int.J.Curr.Microbiol.App.Sci 2018 7 8 291-307 International Journal of Current Microbiology and Applied Sciences ISSN 2319-7706 Volume 7 Number 08 2018 Journal homepage http www.ijcmas.com Original Research Article https doi.org 10.20546 ijcmas.2018.708.034 Antidiabetic and Antilipidemic Effect of Khaya senegalensis Ethanolic Bark Extract in Alloxan Induced Diabetic Wistar Rats R.U. Ukpanukpong1 J.O. Ajani2 W.A. Omang1 M.A. Adejorin2 M.U. Eteng1 and E.U. Eyong1 1 Department of Biochemistry University of Calabar Calabar-Nigeria 2 Department of Chemical Sciences Biochemistry Unit Joseph Ayo Babalola University Ikeji- Arakeji Nigeria Corresponding author ABSTRACT This study investigated the anti-diabetic effect of ethanolic bark extract of Khaya senegalensis in Alloxan-induced diabetic albino Wistar rats. Sixty 60 female albino rats were randomly placed into six 6 study groups of ten 10 animals designated as non- diabetic control NDC diabetic control DC and diabetic extract treated groups DSB1 DSB2 and DSB3 receiving varying extract concentration of 100mg kg 200mg kg and Keywords 400mg kg body weight respectively. Animals were sacrificed after 28 days of treatment and blood was obtained for biochemical analysis. Body weight indices obtained from this Phytochemicals Glucose level study revealed a decrease p Int.J.Curr.Microbiol.App.Sci 2018 7 8 291-307 changes. Genetic predisposition is also a Khaya senegalensis has been reported to factor contributing to this menace Wild et al. possess free radical scavenging activity 2004 . Key features in the pathogenesis of Lompo et al. 2007 . The seeds and leaves are diabetes mellitus are decreased ability of also used to treat fever and headache while the insulin to stimulate glucose uptake in root extract is used to treat mental illness peripheral tissues insulin resistance and β-cell leprosy and syphilis