The first line of treatment in Diabetes mellitus includes the use of oral hypoglycemic agents which are associated with several side effects. Herbal agents are known for their effectiveness due to their fewer side effects and relatively low cost. Umbelliferone, a coumarin has been reported to reduce or decrease blood glucose, elevated plasma insulin, protein profile, and cause hypolipidemic effect. Six groups of rats were used as control, diabetic control, umbelliferone at 20 mg/kg ., umbelliferone at 40 mg/kg . and combination of glibenclamide and umbelliferone at 20 mg/kg b. wt., was used in the study |
