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Synthesis of arylidene dihydropyrimidinones and thiones catalyzed by iron (III) phosphate

In this paper, the synthesis of arylidene heterobicyclicpyrimidinones and thiones is reported by condensation of aromatic aldehydes, cyclopentanone, and urea or thiourea in the present of FePO4 as the green and recyclable catalyst. | Synthesis of arylidene dihydropyrimidinones and thiones catalyzed by iron III phosphate Current Chemistry Letters 7 2018 87 92 Contents lists available at GrowingScience Current Chemistry Letters homepage www.GrowingScience.com Synthesis of arylidene dihydropyrimidinones and thiones catalyzed by iron III phosphate Fatemeh Moradia and Farahnaz K. Behbahania a Department of Chemistry Karaj Branch Islamic Azad University Karaj Iran CHRONICLE ABSTRACT Article history In this paper the synthesis of arylidene heterobicyclicpyrimidinones and thiones is reported by Received April 28 2018 condensation of aromatic aldehydes cyclopentanone and urea or thiourea in the present of Received in revised form FePO4 as the green and recyclable catalyst. Using solvent-free conditions non-toxic and June 29 2018 inexpensive materials simple and clean work-up relatively short reaction times and high Accepted August 12 2018 yields of the products are the advantages of this method. Also some new derivatives of Available online arylidene dihydropyrimidinones and thiones were prepared by this green method. August 12 2018 Keywords Arylidene Iron III phosphate Heterobicyclic Pyrimidinones Urea Thiourea 2018 Growing Science Ltd. All rights reserved. 1. Introduction Pyrimidinones are used in various pharmaceutical and biochemical fields.1 2 Therefore an interest for the synthesis of 3 4-dihydropyrimidin-2 1H -ones DHPMs and their derivations is tremendously increasing.3 One of the most important functionalized pyrimidinones is fused derivatives with an arylidene group. These heterocyclic compounds are significant intermediates for the preparation of many biologically active products. For example some of them show a broad-spectrum antitumor activity.4 Because of the various therapeutic utility of arylidene heterobicyclicpyrimidinones a number of synthesis routs for these derivatives were developed.5 In most cases using strong Brönsted acid such as HCl or base such as sodium alkoxide or .