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Distinct genomic and epigenomic features demarcate hypomethylated blocks in colon cancer

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Large mega base-pair genomic regions show robust alterations in DNA methylation levels in multiple cancers. A vast majority of these regions are hypomethylated in cancers. These regions are generally enriched for CpG islands, Lamin Associated Domains and Large organized chromatin lysine modification domains, and are associated with stochastic variability in gene expression. |

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Distinct genomic and epigenomic features demarcate hypomethylated blocks in colon cancer
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