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Modification of glycan expression in Staphylococcus epidermidis to prevent biofilm formation

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Staphylococcus epidermidis is a common commensal of the skin and mucous membranes of humans. However, it is a common cause of nosocomial infection especially infection associated with the insertion of biomedical devices. Glycans have been shown to mediate vast majority of biological processes and its alterations have been reported to be used as biomarkers and applied in diagnosis of malignancies and infections. The absolute mean Optical Density (OD450nm) of the biofilm was calculated as 0.248± 0.044SD and the biofilm was observed to strongly adhere to the microtitre plate surface. |

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