Đang chuẩn bị liên kết để tải về tài liệu:
Synthesis and bioactivities of 1-(4-hydroxyphenyl)-2-((heteroaryl)thio)ethanones as carbonic anhydrase I, II and acetylcholinesterase inhibitors

Không đóng trình duyệt đến khi xuất hiện nút TẢI XUỐNG

The discovery of enzyme targeting inhibitors is a popular area of drug research. Biological activities of the compounds bearing phenol and heteroaryl groups make them popular groups in drug design targeting important enzymes such as acetylcholinesterase (AChE, E.C.3.1.1.7) and carbonic anhydrases (CAs, EC 4.2.1.1). The compounds 2 and 4 were found potent AChE inhibitors with the Ki values of 22.13 ±1.96 nM and 23.71 ±2.95 nM, respectively, while the compounds 2 (Ki = 8.61 ±0.90 nM, on hCA I) and 1 (Ki = 8.76 ±0.84 nM, on hCA II) had considerable CAs inhibitory potency. The lead compounds may help the scientists for the rational designing of an innovative class of drug candidates targeting enzyme-based diseases. |

TÀI LIỆU LIÊN QUAN

The logic of chemical synthesis

ECE 551 Digital Design And Synthesis: Lecture 8

Summary of environmental technique doctoral thesis: Synthesis of silver, copper, iron nanoparticles and their applications in controlling cyanobacterial blooms in the fresh water body

Semi-synthesis of some heterocyclic triterpene derivatives on the basis of allobetulin

Challenges to qualitative evidence synthesis – Aiming for diversity and abstracting without losing meaning

Synthesis of nanozeolites and nanozeolite-based FCC catalysts, and their catalytic activity in gas oil cracking reaction

Lecture BSc Multimedia - Chapter 5: Digital audio synthesis

Advances in polymer based Friedlander quinoline synthesis

ECE 551 Digital Design And Synthesis: Lecture 9

Lecture Principles of biochemistry - Chapter 16 (part 4): Synthesis of eicosanoids, glycerolipids and isoprenoids
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.