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Synthesis and antimicrobial investigation of some 5H -pyridazino[4,5-b]indoles

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Synthesis and in vitro antimicrobial activities are reported for a series of 1,3,5-substituted 4-oxo-3,4-dihydro5H -pyridazino[4,5- b]indole derivatives. Corresponding pyridazino[4,5- b]indoles were prepared from ethyl 3-formyl-1H - indole-2-carboxylate precursors and the functional group in question was installed with hydrazine and its derivatives. The purity and primary structures of pyridazino[4,5- b]indole were confirmed by IR, 1H NMR, and 13 C NMR spectroscopy and elemental analyses. |

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