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Serum apolipoprotein B to apolipoprotein A-I ratio is an independent predictor of liver metastasis from locally advanced rectal cancer in patients receiving neoadjuvant chemoradiotherapy plus surgery

The ratio of serum apolipoprotein B (apoB) to apolipoprotein A-I (apoAI) had been reported as a prog‑ nostic factor in colorectal cancer. This retrospective study aimed to assess the implication of apoB-to-apoAI ratio in predicting liver metastasis from rectal cancer (RC). | Chen et al. BMC Cancer 2022 22 7 https doi.org 10.1186 s12885-021-09101-y RESEARCH Open Access Serum apolipoprotein B to apolipoprotein A-I ratio is an independent predictor of liver metastasis from locally advanced rectal cancer in patients receiving neoadjuvant chemoradiotherapy plus surgery Chen Chen1 2 Wei Yi3 Zhi fan Zeng1 2 Qiao xuan Wang1 2 Wu Jiang2 4 Yuan hong Gao1 2 and Hui Chang1 2 Abstract Background The ratio of serum apolipoprotein B apoB to apolipoprotein A-I apoAI had been reported as a prog nostic factor in colorectal cancer. This retrospective study aimed to assess the implication of apoB-to-apoAI ratio in predicting liver metastasis from rectal cancer RC . Methods The clinical data of 599 locally advanced RC patients treated with chemoradiotherapy followed by surgery were reviewed. Serum apoAI apoB and apoB-to-apoAI ratio were analyzed for their correlation with the liver-metasta sis-free other-metastasis-free and overall survivals together with the pretreatment and postsurgical pathoclinical fea tures of the patients. Univariate and multivariate survival analyses were realized through the Kaplan-Meier approach and Cox model respectively. Hazard ratios HRs and 95 confidence intervals CIs were calculated for independent predictors. Results Carbohydrate antigen 19 9 26.3 U ml apoB-to-apoAI ratio 0.63 tumor regression grade 5 3 pT4 and pN stage emerged as independent predictors of poorer liver-metastasis-free survival. The hazard ratios were 1.656 95 CI 1.094 2.506 1.919 95 CI 1.174 3.145 1.686 95 CI 1.053 2.703 1.890 95 CI 1.110 3.226 and 2.012 95 CI 1.314 2.077 respectively. Except apoB-to-apoAI ratio the other 4 factors were also independent predictors of poorer other-metastasis-free and overall survivals. And the independent predictors of poorer overall survival also included age 67 years old distance to anal verge Chen et al. BMC Cancer 2022 22 7 Page 2 of 8 time of merely 19.7 months. Yet the figure could rise to monoclonal antibody iv .